I appreciate your response but after reading the doc, I'm unsure how that helps resolve my issue.
The Neo4jDotNetDemo I downloaded from the neo4j website is throwing the exception in WebApiConfig.cs on the Connect statement:
//Use an IoC container and register as a Singleton
var url = ConfigurationManager.AppSettings["GraphDBUrl"];
var user = ConfigurationManager.AppSettings["GraphDBUser"];
var password = ConfigurationManager.AppSettings["GraphDBPassword"];
var client = new GraphClient(new Uri(url), user, password);
client.Connect();