You should be able to do anything you want to a Neo4j instance via the python driver as long as you have your credentials via bolt connection. The Neo4j desktop isn't required to do anything but it's a great tool to help you visualize what you're doing and ensure what you're doing with the driver is correct. I've created a number of graphs with just the drivers and some excel spread sheets, though of course you can do it with CSV, JSON, etc. Are you looking for anything specific?