Neo4j DB down intermittently

Dear Team,

We are using Neo4j enterprise 3.5.5 version in our environment for one of our inventory project. We are facing very unusual problem of neo4j DB down intermittently since last 2 weeks. There is no change at database end even no load on database server.
I am attaching part of Debug.log file for analysis.
db_down_log.txt (497.1 KB)